The thermal decomposition behaviour of the grafted products, ethyl cellulose and. The plasma halflife of the drug has been estimated to range from 4 to 6 h, so the recommended dose in adults and children is usually given every 4 to 6 h. Extensional flow response in capillary breakup, jetting and in a crossslot extensional rheometer vivek sharma 1,2, simon j. Typically, aqualon ec is used as a nonswellable, insoluble component in matrix or coating systems. Cellulose natural polymers and biopolymers sigmaaldrich.
The present study was conducted to prepare sustained release microspheres of naproxen sodium using ethyl cellulose ethocel 20 cps polymer. Poly vinyl pyrrolidone pvp and ethyl cellulose ec were used as the polymer. Hydrophobically modified polymers hmp in paint is the basis for this thesis and has therefore got a separate section section 1. The heat is required to dissolve the ethyl cellulose in the vegetable oil 6. Ethyl cellulose ec is an important commercial cellulose derivative where ethoxy groups have replaced hydroxyl groups on the repeating glucose units. Ethyl cellulose is a widely used excipient in pharmaceutical applications. Cellulose is the most abundant polysaccharide found in nature. Triethyl citrate tec and dibutyl sebacate dbs were the plasticizers used while hydroxypropyl methyl cellulose hpmc was used as the poreformer. Ga is a watersoluble molecule comprised of a hydrophilic part two moieties of glucuronic acid and a hydrophobic frag. Based on these considerations, the present work investigates the means for the efficient encapsulation of salbutamol sulphate into ethyl cellulose microspheres using woo emulsion solvent. Only regions of low penetrant concentration were chosen in order to minimize hysteresis effects associated with slow relaxation of polymer chains.
The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride pvccoated concentric spinneret was employed. The properties of ethyl cellulose sustained release products, including film coated tablets 7, microspheres 8,9. Tunable biphasic drug release from ethyl cellulose. It is mainly used as a thinfilm coating material for coating paper, vitamin and medical pills, and for thickeners in cosmetics and in industrial. Different types of technical cellulose acetates were used and their ability to form such cellulose beads was characterized. Rpv2 polymer viscometer suitable for determining the dynamic viscosity of ethyl cellulose samples in accordance with standard methods of test. May 24, 2018 ethylcellulose is a freeflowing, white to light tan powder used in the pharmaceutical and food manufacturing industries. Study of ethyl cellulose based sustained release microspheres of. The ethyl cellulose is dissolved in a mixture of toluene and ethanol. Design and characterization of carbopolhpmcethyl cellulose. Aqualon ec can be used to coat one or more active ingredients of a tablet to prevent them from.
Produced by the reaction of alkaline cellulose with ethyl chloride. Ethyl cellulose or ethylcellulose is a derivative of cellulose in which some of the hydroxyl groups on the repeating glucose units are converted into ethyl ether groups. The aim of this thesis is to provide useful knowledge for the development of new hydrophobically modified polymers with improved properties primarily for the paint application. Regdon jr study of effect of plasticizer on the structure and surface characteristics of. Ethyl cellulose article about ethyl cellulose by the. Usa home product directory materials science polymer science polymers natural polymers and biopolymers cellulose. Ec is currently used in pharmaceutical applications for micro encapsulation of actives, controlledrelease matrix systems. Its use is presently requested in the formulation of food supplements in dry applications e. Sublime treatment caring hair oil with soft touch is a hair serum that helps repair damaged hair, and delivers a light feel and a truly sparkling boost to dull hair. A cookie is a small file of letters and numbers that we put on your computer if you agree. Aqualon ec is soluble in a wide range of organic solvents. Preparation and characterization of salbutamol sulphate. Three different plasticizers namely polyethyleneglycol.
The psl rheotek rpv2 determins the dynamic viscosity of ethyl cellulose using glass capillary viscometers in accordance with standard methods of test. Ethylcellulose is used in pharmaceutical technology as a coating agent. Polymer science and engineering is a multidisciplinary stem field focused on this special class of molecules. However, there was no such literature reported for the encapsulation of salbutamol sulphate by woo method using ethyl cellulose as retardant polymer. The rheology of aqueous solutions of ethyl hydroxyethyl cellulose ehec and its hydrophobically modified analogue hmehec ii. Hydroxy propyl methyl cellulose, ethyl cellulose, hec. Recently, the formation of liquid crystalline systems from solutions in water and organic solvents of cellulose and its derivatives, including hydroxypropyl cellulose hpc, ethyl cellulose ec, cellulose di and triacetates ca. Dasbach the dow chemical company, midland, michigan 48674, usa introduction ethylcellulose ec is a waterinsoluble polymer, which has been used successfully for coating applications in drug delivery with. The polymer is made by free radical polymerization under high pressure conditions. Tri ethyl citrate tec and dibutyl sebacate dbs were the plasticizers used while hydroxypropyl methyl cellulose hpmc was used as the poreformer. Bacterial translocation and intestinal capillary permeability following major liver resection in the rat. This manuscript reports a new type of drugloaded coreshell nanofibers that provide tunable biphasic release of quercetin. Only regions of low penetrant concentration were chosen in order to minimize hysteresis effects.
While complete etherification is possible yielding triethyl cellulose, usually only to 2 to 2. Three different plasticizers namely polyethyleneglycol 600. Preparation of ethyl cellulose nanoparticles by solvent. Ethyl cellulose general information, process, products.
Product safety assessment ethocel ethylcellulose polymers. Ethyl cellulose containing 4648% or more of ethoxyl groups is freely soluble in ethanol, methanol, toluene and ethyl acetate. Ethyl cellulose c6h7o2oh3xoc2h5xn, the ethyl ether of cellulose. Polymer materials are ubiquitous in almost every aspect of modern life, and advances in the field enable scientific and technological breakthroughs in a wide range of technical applications. The mixing is influenced by the concentration and nature of additive. The drugpolymer mixture was mixed well and then slowly emulsified into 100 ml of paraffin oil that contained 1 ml of span 80 as an emulsifier. Ethyl cellulose prepared at the 26th jecfa 1982, published in fnp 25 1982 and fnp 52 1992. Ethyl cellulose ec is a partly oethylated cellulose ether derivative. Thermal study of ethyl cellulose coating films used for modified release mr dosage forms. Utilization of ethyl cellulose polymer and waste materials. In another study, it was reported that higher storage relative humidity resulted in a decrease in both tensile strength and youngs modulus of beads coated with eudragit rs 30drl 30d containing methylparaben.
The number of ethyl groups can vary depending on the manufacturer. Hercules company can be divided into three typesk,n,and t. Kenji kamide, in cellulose and cellulose derivatives, 2005. The thermal decomposition behaviour of the grafted products, ethyl cellulose and homopolymers was investigated using. Influence of cellulose polymers type on in vitro controlled release. It is available in a variety of grades, which differ in viscosity. The development of green alternatives for petroleumbased plastics is essential for the protection of our environment and its ecosystems. Ethylcellulose polymers have been approved by the eu in food applications since the end of. Ethylcellulose is a freeflowing, white to light tan powder used in the pharmaceutical and food manufacturing industries. For indirect food use such as in paper and paperboard that might contact food, ethyl cellulose is considered generally recognized as safe gras by the u.
The ethyl cellulose of each grade can in turn form 30 kinds of products according to the differences in the viscosity. Preparation of ethyl cellulose nanoparticles by solventdisplacement using the conventional method and a recirculation system 175 drugs, but holds the appealing potential of being able to transport watersoluble drugs as well. Effect of hydroxypropyl methylcellulose and ethyl cellulose. The drug polymer mixture was mixed well and then slowly emulsified into 100 ml of paraffin oil that contained 1 ml of span 80 as an emulsifier. It is a linear polymer composed of glucopyranose residues, where the. It is mainly used as a thinfilm coating material for coating paper, vitamin and medical pills, and for. The decrease in prph release was observed with an increase in both the formulation variables and as the carbopol. Hydrophobically modified polymers lunds universitet. Because of its short biological halflife and low oral dose of 5 mg, salbutamol sulphate. Here, we demonstrate broadband uvblocking, highly transparent composite nanopaper films from a waste source of cellulose nanofibrils with embedded tunable uvabsorbing nanoparticles nps from ethyl cellulose. Ethyl cellulose ec is a nontoxic, stable, compressible, inert, hydrophobic polymer that has been widely used to prepare pharmaceutical dosage forms. Usa home product directory materials science polymer science polymers natural polymers and biopolymers.
It is a linear polymer consisting of 6member ether rings dglucose or dextrose linked together covalently by ether groups, the socalled glycosidic bonds. C using calibrated suspendedlevel ubbelohde type viscometers with corresponding sizes for the dynamic. The rheology of aqueous solutions of ethyl hydroxy ethyl cellulose ehec and its hydrophobically modified analogue hmehec ii. The compatibilizer is an amphiphilic block copolymer consisting of two different blocks which have different functions. Effects of plasticizers, additives, and solvents karen a. Ethyl cellulose viscosity 300 cp, 5 % in tolueneethanol 80. Metals and arsenic specifications revised at the 57th jecfa 2001. Thermal study of ethyl cellulose coating films used for modified release mr dosage. Aqueous solutions of ethyl hydroxyethyl cellulose and hydrophobic modified ethyl hydroxyethyl cellulose polymer. Ethyl cellulose is also used in the food industry as an emulsifier. In this study, the effect of ethylcellulose ec and 6 types of hydroxypropylmethylcellulose methocel k100m, k100mprcr, k15mprcr, k4mprcr, k4m pr. The rheology of aqueous solutions of ethyl hydroxyethyl.
Ethocel ethylcellulose edit pdf torrent polymers are colorless. Since the reactivity ratio between ethylene and va is close to 1, va monomers are almost randomly distributed on the. Ethyl cellulose polymer has been used as a coating material for oral sustainedrelease dosage forms since 1985 1. Physical tuning of cellulosepolymer interactions utilizing. Ethyl cellulose containing 4648% or more of ethoxyl groups is freely soluble in. Ethyl cellulose microcapsules for protecting and controlled.
Its primary release mechanism is drug diffusion across a waterinsoluble membrane, explained rina chokshi, phd, project leader, controlled release technology, fmc biopolymer. Pdf study of ethyl cellulose based sustained release. First the different types of cellulose acetates were characterized by means of solubility. The aim of this investigation was to formulate, characterize and evaluate etoricoxib et loaded.
Ethyl cellulose rpv2 polymer viscometer auto viscometers. Sublime treatment caring hair oil with soft touch by dow. Study of the widely used ethylcellulose polymer as film forming and matrix former agent ph. The properties of ethyl cellulose sustained release products, including film coated tablets 7, microspheres 8,9, microcapsules 10 and matrix tablets. Influence of storage conditions and type of plasticizers. Sorption and diffusion of c 4 and c 5 hydrocarbons have been studied in thin films of ethyl cellulose in the temperature range 30 to 80c. Ethyl cellulose ec is an inert, biocompatible, nonionic water insoluble polymer widely used to prepare slowrelease formulations of drugs due to its controlled release property 4. Fully biobased highly transparent nanopaper with uvblocking. The homogeneous grafting of both poly ethylene glycol allenyl methyl ether macromonomer pega39, and 2acrylamido2methylpropane sulphonic acid amps onto ethyl cellulose ec was carried out in benzene and benzene. Recently, the formation of liquid crystalline systems from solutions in water and organic solvents of cellulose and its derivatives, including hydroxypropyl cellulose hpc, ethyl cellulose ec, cellulose di and triacetates ca has. Aqualon ethylcellulose ec is a cellulose ether distinguished by its versatility.
It is prepared from wood pulp or cotton by treatment with alkali and ethylation of the alkali cellulose with ethyl chloride. Ethyl cellulose or ethylcellulose is a derivative of cellulose in which some of the hydroxyl groups on the repeating glucose units are converted into ethyl ether. Reaction scheme of ethylene vinyl acetate copolymer polymerization evas are commonly available up to 40% vinyl acetate va. Studies on the interaction of water with ethylcellulose. A group adi not specified was established at the 35th jecfa 1989. Fully biobased highly transparent nanopaper with uv. Thermal decomposition behaviour of ethyl cellulose grafted. Ethyl cellulose containing less than 4648% of ethoxyl groups is freely soluble in tetrahydrofuran, methyl acetate and aromatic hydrocarbon ethanol mixtures. December 5, 2014 the dow chemical company page 2 of 7 ethylcellulose polymers are used in a variety of pharmaceuticals, personal care products, foods, ceramics, pastes, inks, and specialty coatings.
1244 480 890 1548 516 510 556 1425 483 1023 84 1366 34 723 733 576 1071 1037 1464 659 1166 190 1454 224 509 551 409 619 895 40 844 1014 835 122 448 1406 1401 779 730 273 1200 1112 624 1210 1205 1231 1439